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Scientific Research and Documents for Medicinal Marijuana

Many Universities and research centers have conducted scientific studies on cannabinoids and their effects on disease. Below is a sampling of these studies. Studies are categorized according to type of disease, such as cancer, multiple sclerosis, Alzheimer’s, etc. Read up on the benefits of medicinal marijuana and how it can help improve your quality of life. Any questions you may have, please contact our team!

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Amyotrophic Lateral Sclerosis (ALS)
  • Delayed disease progression in ALS mice by treatment with a cannabinoid
  • Marijuana in the management of amyotrophic lateral sclerosis
  • Cannabis Relieves Lou Gehrigs Symptoms

Alzheimer’s Disease
  • Prevention of Alzheimer’s Disease Pathology by Cannabinoids
  • Marijuana Slows Alzheimer’s Decline
  • Cannabinoids reduce the progression of Alzheimer’s disease in animals

Arthritis
  • Marijuana Extract Helps Arthritis Pain
  • Rheumatoid arthritis, Cannabis based medicine eases pain and suppresses disease
  • Arthritis and Cannabis

Cancer – Breast
  • Suppression of Nerve Growth Factor Trk Receptors and Prolactin Receptors by Endocannabinoids Leads to Inhibition of Human Breast and Prostate Cancer Cell Proliferation
  • Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
  • 9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer through Cdc2 Regulation
  • Cannabidiol inhibits tumour growth in leukaemia and breast cancer in animal studies
  • Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

Cervical Cancer
  • Marijuana Ingredients Slow Invasion by Cervical and Lung Cancer Cells
  • Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

Colorectal Cancer
  • Possible endocannabinoid control of colorectal cancer growth
  • The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
  • The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3KAKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells

Cancer – Breast
  • Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
  • Delta9-tetrahydrocannabinol induces apoptosis in C6 glioma cells
  • Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
  • Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor1
  • Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
  • Cannabis extract makes brain tumors shrink, halts growth of blood vessels
  • Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
  • Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival

Leukemia
  • Cannabinoids induce incomplete maturation of cultured human leukemia cells
  • Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway
  • Cannabidiol-Induced Apoptosis in Human Leukemia Cells : A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
  • Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach

Lymphoma
  • Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
  • Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
  • Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation

Lung Cancer
  • In vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomas
  • Delta-9Tetrahydrocannabinol inhibits growth and metastasis of lung cancer
  • Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows

Melanoma
  • Cannabinoid receptors as novel targets for the treatment of melanoma
  • Cannabinoid receptor-1 modulation induces apoptosis of human melanoma cells

Pancreatic Cancer
  • Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells via Endoplasmic Reticulum Stress–Related Genes
  • Cannabinoids in pancreatic cancer: Correlation with survival and pain

Prostate Cancer
  • Δ9-Tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
  • Cannabinoid receptors agonist WIN-55,212-2 inhibits angiogenesis, metastasis and tumor growth of androgen-sensitive prostate cancer cell CWR22Rnu1 xenograft in athymic nude mice

Cancer – Undifferentiated
  • Cannabinoids: Potential Anticancer Agents
  • Inhibition of tumor angiogenesis by cannabinoids
  • Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
  • Cannabinoids for Cancer Treatment: Progress and Promise
  • Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents
  • Antitumorigenic Effects of Cannabinoids beyond Apoptosis

Diabetes
  • Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
  • Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
  • Cannabidiol arrests onset of autoimmune diabetes in NOD mice
  • Beneficial effects of a Cannabis sativa extract on diabetes induced neuropathy and oxidative stress